In a rapidly changing and complex socio-economic-political environment, decision-makers need to address the challenges of competitiveness, accelerated technological change and globalisation of a more and more knowledge-based economy. However, they often lack a comprehensive knowledge base and a structured stakeholder input to take informed RTDI-related decisions. To help regional actors develop novel strategies and approaches to RTDI decision-making, the RegStrat project explored new ways to apply SPI tools such as Foresight, Technology Assessment, Innovation Audits, Evaluation and Benchmarking.